| http://purl.uniprot.org/citations/18962896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18962896 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10 is a multifunctional cytokine that plays a critical role in maintaining the balance between immunity and tolerance. Previously, we identified proximal regulatory elements and alterations of chromatin structure in the IL-10 gene loci of Th1 and Th2 cells. We have now characterized a crucial cis-regulatory element, CNS-9, located 9kb upstream of the transcription start site in IL-10 gene loci. The CNS-9 region is highly conserved in vertebrate genomes, and contains clustered NFAT and IRF binding motifs. In vitro binding of NFAT1 and IRF4 to the CNS-9 region was observed by EMSA. Furthermore, Th2-preferential in vivo binding of NFAT1 and IRF4 to the CNS-9 region was observed by ChIP. Cyclosporine A treatment on wild type Th2 cells or Th2 cells derived from NFAT1 knockout (NFAT1(-/-)) mice showed significantly reduced trans-activity of CNS-9. The Th2 subset-specific enhancer activity of CNS-9 was upregulated synergistically by NFAT1 and its partner IRF4. Mutations in the binding sites for NFAT1 and IRF4 abrogated its enhancer activity of CNS-9. Collectively, our results establish crucial roles for enhancer element CNS-9, and NFAT1 and IRF4 that bind to it, for IL-10 expression in differential T helper subsets."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2008.07.037"xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Kang K.H."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Matsuyama T."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Hwang K.C."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Yui K."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Lee C.G."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Im S.H."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Kwon H.K."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "So J.S."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Sahoo A."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Son J.S."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Yi H.J."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/author | "Song M.K."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/name | "Mol Immunol"xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/pages | "613-621"xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/title | "A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells."xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/18962896 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18962896 |
| http://purl.uniprot.org/citations/18962896 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18962896 |
| http://purl.uniprot.org/uniprot/#_A2AQC8-mappedCitation-18962896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18962896 |
| http://purl.uniprot.org/uniprot/#_A0A1Y7VIT1-mappedCitation-18962896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18962896 |
| http://purl.uniprot.org/uniprot/#_B3VI66-mappedCitation-18962896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18962896 |