| http://purl.uniprot.org/citations/18971210 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18971210 | http://www.w3.org/2000/01/rdf-schema#comment | "Release of bilateral ureteral obstruction (BUO) is associated with nephrogenic diabetes insipidus (NDI) and a reduced abundance of the vasopressin-regulated aquaporins. To evaluate the role of the vasopressin type 2 receptor (V2R), we determined V2R abundance in kidneys from rats subjected to 24-h BUO or 24-h unilateral ureteral obstruction (UUO) followed by 48-h release. Because angiotensin II type 1 (AT1) receptor blockade attenuates postobstructive polyuria and aquaporin-2 (AQP2) downregulation, we examined the effect of AT1 receptor blockade on AQP2 phosphorylated at serine 256 (pS256-AQP2) and V2 receptor complex abundance in kidney inner medulla (IM). Furthermore, cAMP generation in sodium fluoride- and forskolin-stimulated inner medullary membrane fractions was studied after release of BUO. V2R was significantly reduced to 12% of sham levels in IM and to 52% of sham levels in cortex and outer stripe of outer medulla (OSOM) from BUO rats. In UUO rats, V2R abundance in the obstructed kidney IM decreased to 35% of sham levels, whereas it was comparable to sham levels in the nonobstructed kidney IM. No significant change was observed in cortex and OSOM. AT1 receptor blockade attenuated V2R, pS256-AQP2, and G(s)alpha protein downregulation in IM and partially reversed the obstruction-induced inhibition of sodium fluoride- and forskolin-stimulated cAMP generation in inner medullary membrane fractions from BUO rats. In conclusion, V2R downregulation plays a pivotal role in development of NDI after release of BUO. In addition, we have shown that angiotensin II regulates the V2 receptor complex and pS256-AQP2 in postobstructive kidney IM, probably by stimulating cAMP generation."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.90479.2008"xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Kim S.W."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Fenton R.A."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Nielsen S."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Jensen A.M."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Frokiaer J."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Bae E.H."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/author | "Norregaard R."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/pages | "F127-34"xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/title | "Angiotensin II regulates V2 receptor and pAQP2 during ureteral obstruction."xsd:string |
| http://purl.uniprot.org/citations/18971210 | http://purl.uniprot.org/core/volume | "296"xsd:string |
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| http://purl.uniprot.org/citations/18971210 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18971210 |
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