| http://purl.uniprot.org/citations/18974388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18974388 | http://www.w3.org/2000/01/rdf-schema#comment | "Senescence of endothelial cells (ECs) may contribute to age-associated cardiovascular diseases, including atherosclerosis and hypertension. The functional and gene expression changes associated with cellular senescence are poorly understood. Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth factor (TGF)-beta receptor involved in vascular remodeling and angiogenesis. As evidenced by RT-PCR, the S/L ratio of endoglin isoforms was increased during senescence of human ECs in vitro, as well as during aging of mice in vascularized tissues. Next, the effect of S-endoglin protein on the TGF-beta receptor complex was studied. As revealed by coimmunoprecipitation assays, S-endoglin was able to interact with both TGF-beta type I receptors, ALK5 and ALK1, although the interaction with ALK5 was stronger than with ALK1. S-endoglin conferred a lower proliferation rate to ECs and behaved differently from L-endoglin in relation to TGF-beta-responsive reporters with ALK1 or ALK5 specificities, mimicking the behavior of the endothelial senescence markers Id1 and plasminogen activator inhibitor-1. In situ hybridization studies demonstrated the expression of S-endoglin in the endothelium from human arteries. Transgenic mice overexpressing S-endoglin in ECs showed hypertension, decreased hypertensive response to NO inhibition, decreased vasodilatory response to TGF-beta(1) administration, and decreased endothelial nitric oxide synthase expression in lungs and kidneys, supporting the involvement of S-endoglin in the NO-dependent vascular homeostasis. Taken together, these results suggest that S-endoglin is induced during endothelial senescence and may contribute to age-dependent vascular pathology."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.org/dc/terms/identifier | "doi:10.1161/circresaha.108.176552"xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Bernabeu C."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Blanco F.J."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Perez-Gomez E."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Quintanilla M."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Velasco S."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Langa C."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Lopez-Novoa J.M."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Rodriguez-Barbero A."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Grande M.T."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/author | "Oujo B."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/pages | "1383-1392"xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/title | "S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology."xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://purl.uniprot.org/core/volume | "103"xsd:string |
| http://purl.uniprot.org/citations/18974388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18974388 |
| http://purl.uniprot.org/citations/18974388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18974388 |
| http://purl.uniprot.org/uniprot/P17813#attribution-1BE110CC85848FF754EECD100CDAC620 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18974388 |
| http://purl.uniprot.org/uniprot/P17813#attribution-4790FDC4A009D44F0A53FE3C811E0579 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18974388 |
| http://purl.uniprot.org/uniprot/P17813#attribution-55334A55AD5D410D13DAA0792FBFA7B2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18974388 |
| http://purl.uniprot.org/uniprot/P17813#attribution-86C5A7BDA995C7D8C9E4946AAC01E018 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18974388 |
| http://purl.uniprot.org/uniprot/#_A8K2X4-mappedCitation-18974388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18974388 |