| http://purl.uniprot.org/citations/18977328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18977328 | http://www.w3.org/2000/01/rdf-schema#comment | "The biochemical mechanisms that underlie hypoxia-induced NF-kappaB activity have remained largely undefined. Here, we find that prolonged hypoxia-induced NF-kappaB activation is restricted to cancer cell lines infected with high-risk human papillomavirus (HPV) serotypes. The HPV-encoded E6 protein is necessary and sufficient for prolonged hypoxia-induced NF-kappaB activation in these systems. The molecular target of E6 in the NF-kappaB pathway is the CYLD lysine 63 (K63) deubiquitinase, a negative regulator of the NF-kappaB pathway. Specifically, hypoxia stimulates E6-mediated ubiquitination and proteasomal degradation of CYLD. Given the established role of NF-kappaB in human carcinogenesis, these findings provide a potential molecular/viral link between hypoxia and the adverse clinical outcomes observed in HPV-associated malignancies."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2008.10.007"xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "Massoumi R."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "Mo D."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "Rettig M.B."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "Srivatsan E.S."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/author | "Veena M.S."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/pages | "394-407"xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/title | "Inactivation of the CYLD deubiquitinase by HPV E6 mediates hypoxia-induced NF-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/18977328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18977328 |
| http://purl.uniprot.org/citations/18977328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18977328 |
| http://purl.uniprot.org/uniprot/#_P03126-mappedCitation-18977328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/#_P06463-mappedCitation-18977328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/#_P04637-mappedCitation-18977328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/#_Q9NQC7-mappedCitation-18977328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/Q9NQC7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/P06463 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/P04637 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18977328 |
| http://purl.uniprot.org/uniprot/P03126 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18977328 |