| http://purl.uniprot.org/citations/18977754 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18977754 | http://www.w3.org/2000/01/rdf-schema#comment | "Induction of Type I IFNs is a central event in antiviral responses and must be tightly controlled. The protein kinase TBK1 is critically involved in virus-triggered type I IFN signaling. In this study, we identify an alternatively spliced isoform of TBK1, termed TBK1s, which lacks exons 3-6. Upon Sendai virus (SeV) infection, TBK1s is induced in both human and mouse cells and binds to RIG-1, disrupting the interaction between RIG-I and VISA. Consistent with that result, overexpression of TBK1s inhibits IRF3 nuclear translocation and leads to a shutdown of SeV-triggered IFN-beta production. Taken together, our data indicate that TBK1s plays an inhibitory role in virus-triggered IFN-beta signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m805775200"xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Han M."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Luo X."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Deubel V."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Sun B."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Shi M."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Tang H."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Zhong J."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/author | "Ning Q."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/pages | "35590-35597"xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/title | "Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1."xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18977754 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18977754 |
| http://purl.uniprot.org/citations/18977754 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18977754 |