| http://purl.uniprot.org/citations/18978355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18978355 | http://www.w3.org/2000/01/rdf-schema#comment | "TEA domain (TEAD) transcription factors serve important functional roles during embryonic development and in striated muscle gene expression. Our previous work has implicated a role for TEAD-1 in the fast-to-slow fiber-type transition in response to mechanical overload. To investigate whether TEAD-1 is a modulator of slow muscle gene expression in vivo, we developed transgenic mice expressing hemagglutinin (HA)-tagged TEAD-1 under the control of the muscle creatine kinase promoter. We show that striated muscle-restricted HA-TEAD-1 expression induced a transition toward a slow muscle contractile protein phenotype, slower shortening velocity (Vmax), and longer contraction and relaxation times in adult fast twitch extensor digitalis longus muscle. Notably, HA-TEAD-1 overexpression resulted in an unexpected activation of GSK-3alpha/beta and decreased nuclear beta-catenin and NFATc1/c3 protein. These effects could be reversed in vivo by mechanical overload, which decreased muscle creatine kinase-driven TEAD-1 transgene expression, and in cultured satellite cells by TEAD-1-specific small interfering RNA. These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m807461200"xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/author | "Ji J."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/author | "Schramm C."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/author | "Moss R.L."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/author | "Fitzsimons D.P."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/author | "Tsika R.W."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/author | "Simmer G."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/pages | "36154-36167"xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/title | "Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype."xsd:string |
| http://purl.uniprot.org/citations/18978355 | http://purl.uniprot.org/core/volume | "283"xsd:string |
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