| http://purl.uniprot.org/citations/18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18979509 | http://www.w3.org/2000/01/rdf-schema#comment | "DC are a highly heterogeneous population that plays a critical role in host defense. We previously demonstrated that virus infection induces BM plasmacytoid DC (pDC) differentiation into CD11b(+) conventional DC (cDC) upon in vitro culture with Fms-like tyrosine kinase 3 ligand (Flt3L). Here we use immunoglobulin D-J rearrangements and pDC adoptive transfer to provide definitive proof supporting BM pDC conversion into CD11b(+) cDC during in vivo viral infection. We show that in vivo BM pDC conversion into CD11b(+) cDC relates to enhanced ability to prime virus-specific T cells. Furthermore, we demonstrate that in vivo pDC conversion does not rely on viral infection of BM pDC, but instead is mediated by type I IFN signaling. Finally, by exploiting recently identified pDC-specific Ab, we provide further characterizations of the BM pDC fraction that exhibits this broader developmental plasticity. Collectively, these data indicate that BM pDC actively contribute to the CD11b(+) cDC pool during in vivo viral infection and delineates molecular, functional, and phenotypic features of this novel developmental pathway."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838282"xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/author | "Oldstone M.B."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/author | "Blasius A.L."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/author | "Welch M.J."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/author | "Zuniga E.I."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/author | "Liou L.Y."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/pages | "3388-3394"xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/title | "In vivo conversion of BM plasmacytoid DC into CD11b+ conventional DC during virus infection."xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/18979509 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18979509 |
| http://purl.uniprot.org/citations/18979509 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18979509 |
| http://purl.uniprot.org/uniprot/#_E9Q604-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |
| http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |
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| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |
| http://purl.uniprot.org/uniprot/#_G3UZP7-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |
| http://purl.uniprot.org/uniprot/#_E9PWM1-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |
| http://purl.uniprot.org/uniprot/#_G5E8F1-mappedCitation-18979509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18979509 |