| http://purl.uniprot.org/citations/18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18981102 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-21 is a member of the type I cytokine family related most closely to IL-2 and IL-15. IL-21 is a pleiotropic cytokine, produced by T, NKT, and dendritic cells, which modulates lymphoid and myeloid cell functions. Besides its activities on normal lymphoid cells, it has been shown that IL-21 is a growth factor for myeloma cells. In the present study, we demonstrate that IL-21 generated myeloma colonies from 9 of 24 human myeloma cell lines (HMCL) in a collagen-based assay. Of major interest, the capacity of IL-21 to stimulate clonogenicity was restricted to CD45(-) HMCL. We found that IL-21 induced tyrosine phosphorylation of STAT-3, STAT-1, and Erk1/2. Interestingly, an Akt activation was observed lately after 30 min to 1 h of IL-21 stimulation, indicating that this Akt phosphorylation could be due to an IGF-1 autocrine loop. This hypothesis was sustained both by the fact that IL-21 treatment induced an IGF-1 mRNA synthesis and that an antagonistic anti-IGF-1 receptor mAb (AVE1642) strongly inhibits the IL-21-induced clonogenicity. Thus, we demonstrated by quantitative PCR that IL-21 induced clonogenicity through an autocrine IGF-1 secretion in HMCL and primary myeloma cells. Because we have previously demonstrated that CD45 phosphatase inhibits the IGF-1 signaling, this inhibitory effect of CD45 explains why the IL-21-induced clonogenicity was restricted to CD45(-) HMCL. These results support that therapy against IGF-1R, which are presently under investigation in multiple myeloma, could be beneficial, not only to suppress IGF-1-mediated myeloma cell growth, but also IL-21-mediated myeloma cell growth."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.10.6837"xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Moreau P."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Cappellano M."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Amiot M."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Bataille R."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Pellat-Deceunynck C."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Maiga S."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Fraslon C."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Descamps G."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/author | "Menoret E."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/pages | "6837-6842"xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/title | "IL-21 stimulates human myeloma cell growth through an autocrine IGF-1 loop."xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/18981102 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18981102 |
| http://purl.uniprot.org/citations/18981102 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18981102 |
| http://purl.uniprot.org/uniprot/#_A0A1U9WZ84-mappedCitation-18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981102 |
| http://purl.uniprot.org/uniprot/#_A0A224B028-mappedCitation-18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981102 |
| http://purl.uniprot.org/uniprot/#_Q13429-mappedCitation-18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981102 |
| http://purl.uniprot.org/uniprot/#_P05019-mappedCitation-18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981102 |
| http://purl.uniprot.org/uniprot/#_Q5U743-mappedCitation-18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981102 |
| http://purl.uniprot.org/uniprot/#_Q6LD41-mappedCitation-18981102 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981102 |