| http://purl.uniprot.org/citations/18981155 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18981155 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory cytokines, IL-1beta and IL-18. We observed that cellular levels of retinoic acid-inducible gene-I (RIG-I) were enhanced when the pan-caspase inhibitor Z-VAD-fmk or caspase-1-specific inhibitor Z-WEHD-fmk blocked caspase activity. Overexpression of caspase-1 reduced cellular levels of RIG-I and inhibited RIG-I-mediated signaling activity. Enzymatic activity of caspase-1 was necessary to control RIG-I, although it was not a substrate of proteolytic cleavage by caspase-1. Caspase-1 physically interacted with full length RIG-I, but not with mutant forms lacking either the amino- or carboxyl-terminal domains. RIG-I was present in the supernatant of cells transfected with active caspase-1 but not with caspase-4. Stimulating cells with LPS and ATP also induced secretion of endogenous RIG-I in macrophages. Our data suggest a novel mechanism that negatively regulates RIG-I-mediated signaling activity via caspase-1-dependent secretion of RIG-I protein."xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.10.7324"xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/author | "Kim M.J."xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/author | "Yoo J.Y."xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/pages | "7324-7331"xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/title | "Active caspase-1-mediated secretion of retinoic acid inducible gene-I."xsd:string |
| http://purl.uniprot.org/citations/18981155 | http://purl.uniprot.org/core/volume | "181"xsd:string |
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