| http://purl.uniprot.org/citations/18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18981236 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of specialized follicular helper T (T(FH)) cells in the germinal center has become well recognized, but it is less clear how effector T cells govern the extrafollicular response, the dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr) (MRL(lpr)) mouse model of lupus. MRL(lpr) mice lacking the Icos gene have impaired extrafollicular differentiation of immunoglobulin (Ig) G(+) plasma cells accompanied by defects in CXC chemokine receptor (CXCR) 4 expression, interleukin (IL) 21 secretion, and B cell helper function in CD4 T cells. These phenotypes reflect the selective loss of a population of T cells marked by down-regulation of P-selectin glycoprotein ligand 1 (PSGL-1; also known as CD162). PSGL-1(lo) T cells from MRL(lpr) mice express CXCR4, localize to extrafollicular sites, and uniquely mediate IgG production through IL-21 and CD40L. In other autoimmune strains, PSGL-1(lo) T cells are also abundant but may exhibit either a follicular or extrafollicular phenotype. Our findings define an anatomically distinct extrafollicular population of cells that regulates plasma cell differentiation in chronic autoimmunity, indicating that specialized humoral effector T cells akin to T(FH) cells can occur outside the follicle."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20080840"xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Flavell R.A."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Dong C."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Craft J."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Kono D.H."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "DiPlacido L.D."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Marks B.R."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Odegard J.M."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/author | "Poholek A.C."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/pages | "2873-2886"xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/title | "ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://purl.uniprot.org/core/volume | "205"xsd:string |
| http://purl.uniprot.org/citations/18981236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18981236 |
| http://purl.uniprot.org/citations/18981236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18981236 |
| http://purl.uniprot.org/uniprot/#_D0E8G6-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |
| http://purl.uniprot.org/uniprot/#_A2A6A7-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |
| http://purl.uniprot.org/uniprot/#_A5J0L5-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |
| http://purl.uniprot.org/uniprot/#_E9PX58-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |
| http://purl.uniprot.org/uniprot/#_Q3V3X2-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |
| http://purl.uniprot.org/uniprot/#_Q5SUZ7-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |
| http://purl.uniprot.org/uniprot/#_Q5SUZ8-mappedCitation-18981236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18981236 |