| http://purl.uniprot.org/citations/18984593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18984593 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I interferons (IFN-alpha/beta) are essential for immune defense against viruses and induced through the actions of the cytoplasmic helicases, RIG-I and MDA5, and their downstream adaptor molecule IPS-1. TRAF6 and the downstream kinase TAK1 have been shown to be essential for the production of proinflammatory cytokines through the TLR/MyD88/TRIF pathway. Although binding of TRAF6 with IPS-1 has been demonstrated, the role of the TRAF6 pathway in IFN-alpha/beta production has not been fully understood. Here, we demonstrate that TRAF6 is critical for IFN-alpha/beta induction in response to viral infection and intracellular double-stranded RNA, poly(I:C). Activation of NF-kappaB, JNK, and p38, but not IRF3, was impaired in TRAF6-deficient mouse embryo fibroblasts in response to vesicular stomatitis virus and poly(I:C). However, TAK1 was not required for IFN-beta induction in this process, since normal IFN-alpha/beta production was observed in TAK1-deficient mouse embryo fibroblasts. Instead, another MAP3K, MEKK1, was important for the activation of the IFN-beta promoter in response to poly(I:C). Forced expression of MEKK1 in combination with IRF3 was sufficient for the induction of IFN-beta, whereas suppression of MEKK1 expression by small interfering RNA inhibited the induction of IFN-beta by poly(I:C). These data suggest that IPS-1 requires TRAF6 and MEKK1 to activate NF-kappaB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806576200"xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Yoshioka T."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Takaesu G."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Yoshida R."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/author | "Okamoto F."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/pages | "36211-36220"xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/title | "TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway."xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://purl.uniprot.org/core/volume | "283"xsd:string |
| http://purl.uniprot.org/citations/18984593 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18984593 |
| http://purl.uniprot.org/citations/18984593 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18984593 |
| http://purl.uniprot.org/uniprot/Q9Y4K3#attribution-0B30AC8F8271C7A44A6EAB52151A143E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18984593 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGK6-mappedCitation-18984593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18984593 |
| http://purl.uniprot.org/uniprot/#_D3YVX9-mappedCitation-18984593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18984593 |
| http://purl.uniprot.org/uniprot/#_Q14258-mappedCitation-18984593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18984593 |
| http://purl.uniprot.org/uniprot/#_A2AP92-mappedCitation-18984593 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18984593 |