| http://purl.uniprot.org/citations/18985028 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18985028 | http://www.w3.org/2000/01/rdf-schema#comment | "A proteome-wide mapping of interactions between hepatitis C virus (HCV) and human proteins was performed to provide a comprehensive view of the cellular infection. A total of 314 protein-protein interactions between HCV and human proteins was identified by yeast two-hybrid and 170 by literature mining. Integration of this data set into a reconstructed human interactome showed that cellular proteins interacting with HCV are enriched in highly central and interconnected proteins. A global analysis on the basis of functional annotation highlighted the enrichment of cellular pathways targeted by HCV. A network of proteins associated with frequent clinical disorders of chronically infected patients was constructed by connecting the insulin, Jak/STAT and TGFbeta pathways with cellular proteins targeted by HCV. CORE protein appeared as a major perturbator of this network. Focal adhesion was identified as a new function affected by HCV, mainly by NS3 and NS5A proteins."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.org/dc/terms/identifier | "doi:10.1038/msb.2008.66"xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "de Chassey B."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Vidalain P.O."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Jacob Y."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Penin F."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Le Breton M."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Chaboud A."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Lotteau V."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Rabourdin-Combe C."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Tafforeau L."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Hiet M.S."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Andre P."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Mangeot P.E."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Navratil V."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Pradezynski F."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Agaugue S."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Chantier T."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Pellet J."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Davoust N."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Meiffren G."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Aublin-Gex A."xsd:string |
| http://purl.uniprot.org/citations/18985028 | http://purl.uniprot.org/core/author | "Faria B.F."xsd:string |