| http://purl.uniprot.org/citations/18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18986700 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the placental dysfunction in pre-eclampsia (PE). However, it is not known if altered IL-6 receptor signalling and decreased SOCS-3 expression occur in placentas from PE. To study this, we examined IL-6, soluble IL-6R (sIL-6R) and soluble gp130 (sgp130) production by villous tissue from normal and PE placentas. Hypoxia effects on IL-6, sIL-6R and sgp130 production was determined. IL-6R, gp130 and SOCS-3 expression were determined by immunohistochemical staining and by Western blot. Our results showed that under normoxic conditions (21% O(2)), villous tissue from PE placentas produced relative more sgp130, but significantly less IL-6 and sIL-6R (p<0.01) than normal placental tissue. The ratio of sgp130/sIL-6R release was significantly higher by PE placentas than normal placentas, p<0.01. Under hypoxic conditions (2% O(2)), IL-6 production was significantly reduced by both normal (p<0.01) and PE (p<0.05) placental tissue. Hypoxia promoted sgp130 release by normal, but not by PE, placental tissue. Reduced IL-6R and SOCS-3 immunostaining and expression were found in PE placentas. We concluded that increased ratio of sgp130/sIL-6R production and/or reduced sIL-6R production combined with down-regulation of IL-6R and SOCS-3 expression in trophoblasts may lead to less cytokine inhibitory activity in PE placentas, which may account for the increased placental inflammatory response in PE."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.placenta.2008.09.011"xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/author | "Fan R."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/author | "Dong Q."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/name | "Placenta"xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/pages | "1024-1028"xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/title | "Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia."xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/18986700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18986700 |
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| http://purl.uniprot.org/uniprot/#_A0A0A0N0L2-mappedCitation-18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18986700 |
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| http://purl.uniprot.org/uniprot/#_Q13514-mappedCitation-18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18986700 |
| http://purl.uniprot.org/uniprot/#_Q17RA0-mappedCitation-18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18986700 |
| http://purl.uniprot.org/uniprot/#_Q5U0H7-mappedCitation-18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18986700 |
| http://purl.uniprot.org/uniprot/#_O14543-mappedCitation-18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18986700 |
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| http://purl.uniprot.org/uniprot/#_Q5FC03-mappedCitation-18986700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18986700 |