| http://purl.uniprot.org/citations/18987854 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18987854 | http://www.w3.org/2000/01/rdf-schema#comment | "We here describe that soluble HLA-DQ2 (sDQ2) molecules, when expressed in Drosophila melanogaster S2 insect cells without a covalently tethered peptide, associate tightly with the D. melanogaster calcium binding protein DCB-45. The interaction between the proteins is stable in S2 cell culture and during affinity purification, which is done at high salt concentrations and pH 11.5. After affinity purification, the sDQ2/DCB-45 complex exists in substantial quantities next to a small amount of free heterodimeric sDQ2 and large amounts of aggregated sDQ2 free of DCB-45. Motivated by the stable complex formation and our interest in the development of reagents which inhibit HLA-DQ2 peptide binding, we have further characterized the sDQ2/DCB-45 interaction. Several lines of evidence indicate that an N-terminal fragment of DCB-45 is involved in the interaction with the peptide binding groove of sDQ2. Further mapping of this fragment of 54 residues identified a pentadecapeptide with high affinity for sDQ2 which may serve as a lead compound for the design of HLA-DQ2 blockers."xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00251-008-0338-7"xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/author | "Fleckenstein B."xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/author | "Sollid L.M."xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/author | "Bergseng E."xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/author | "Juse U."xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/name | "Immunogenetics"xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/pages | "81-89"xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/title | "Soluble HLA-DQ2 expressed in S2 cells copurifies with a high affinity insect cell derived protein."xsd:string |
| http://purl.uniprot.org/citations/18987854 | http://purl.uniprot.org/core/volume | "61"xsd:string |
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