| http://purl.uniprot.org/citations/18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18989338 | http://www.w3.org/2000/01/rdf-schema#comment | "Prothymosin-alpha (ProTalpha) causes a switch in cell death mode from necrosis to neurotrophin-reversible apoptosis in primary cultured cortical neurons. In the present study, post-ischemic administration (3 or 24 h, intravenously) of recombinant mouse ProTalpha without neurotrophins completely prevented ischemia-induced retinal damage accompanying necrosis and apoptosis, as well as dysfunction assessed by electroretinogram. Treatments with anti-erythropoietin (EPO) or brain-derived neurotrophic factor (BDNF) immunoglobulin G (IgG) reversed ProTalpha-induced inhibition of apoptosis. ProTalpha upregulated retinal EPO and BDNF levels in the presence of ischemia. Moreover, intravitreous administration of anti-ProTalpha IgG or an antisense oligodeoxynucleotide for ProTalpha accelerated ischemia-induced retinal damage. We also observed that ischemia treatment caused a depletion of ProTalpha from retinal cells. Altogether, these results suggest that the systemic administration of ProTalpha switches ischemia-induced necrosis to apoptosis, which in turn is inhibited by neurotrophic factors upregulated by ProTalpha and ischemia. ProTalpha released upon ischemic stress was found to have a defensive role in retinal ischemia."xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2008.159"xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/author | "Fujiwara K."xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/author | "Ueda M."xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/author | "Ueda H."xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/author | "Fujita R."xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/pages | "349-358"xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/title | "Prothymosin-alpha plays a defensive role in retinal ischemia through necrosis and apoptosis inhibition."xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/18989338 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18989338 |
| http://purl.uniprot.org/citations/18989338 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18989338 |
| http://purl.uniprot.org/uniprot/#_A0A087WP98-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/#_P26350-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/#_Q3U8X6-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/#_Q0VGU2-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/#_Q3U6E4-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/#_Q3UA54-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/#_Q8C2T3-mappedCitation-18989338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/A0A087WP98 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/P26350 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/Q0VGU2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18989338 |
| http://purl.uniprot.org/uniprot/Q8C2T3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18989338 |