| http://purl.uniprot.org/citations/18991865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18991865 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress has been implicated as a key event in the degenerative process of dopaminergic neurons; however, the cellular mechanisms underlying chronic oxidative stress-induced neurodegeneration remain to be established. In this study, N27 cells, a dopaminergic neuronal cell line derived from rat mesencephalon, exposed to low doses of H(2)O(2) (0-30 muM for 12-24 hr) exhibited dose- and time-dependent increases in cytotoxicity and ROS generation. In addition, the H(2)O(2)-induced neurotoxicity was accompanied by increased caspase-3 activity and PKCdelta cleavage. Notably, treatment with antioxidants Trolox and MnTBAP or PKCdelta cleavage inhibitor z-DIPD-fmk significantly protected against oxidative stress-induced apoptotic cell death. These results demonstrate that the N27 cell line is a useful model for the study of the chronic low-dose oxidative stress-induced apoptotic cell death cascade and that caspase-3-dependent PKCdelta proteolytic activation may be important in the apoptotic process in dopaminergic neurons undergoing chronic oxidative insult."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.org/dc/terms/identifier | "doi:10.1196/annals.1432.020"xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/author | "Kaul S."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/author | "Song C."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/author | "Anantharam V."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/author | "Kanthasamy A."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/author | "Kanthasamy A.'"xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/author | "Carvour M."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/pages | "197-205"xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/title | "Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://purl.uniprot.org/core/volume | "1139"xsd:string |
| http://purl.uniprot.org/citations/18991865 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18991865 |
| http://purl.uniprot.org/citations/18991865 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18991865 |
| http://purl.uniprot.org/uniprot/#_A0A140UHX0-mappedCitation-18991865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18991865 |
| http://purl.uniprot.org/uniprot/#_A6KG32-mappedCitation-18991865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18991865 |
| http://purl.uniprot.org/uniprot/#_P09215-mappedCitation-18991865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18991865 |
| http://purl.uniprot.org/uniprot/A0A140UHX0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18991865 |
| http://purl.uniprot.org/uniprot/A6KG32 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18991865 |
| http://purl.uniprot.org/uniprot/P09215 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18991865 |