| http://purl.uniprot.org/citations/1899230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1899230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1899230 | http://www.w3.org/2000/01/rdf-schema#comment | "Staurosporine, a potent inhibitor of protein kinase C, arrests fission yeast cell elongation specifically at a stage immediately after cell division. We isolated two genes, which, when carried on multicopy plasmids, confer drug resistance in fission yeast. One, spk1+, encodes a protein kinase highly similar (54% identity) to those encoded by the mammalian ERK1/MAP2 kinase and the budding yeast KSS1 and FUS3 genes. It is not essential for vegetative growth of Schizosaccharomyces pombe cells but is required for conjugation. The spk1+ gene product is a 45-kD protein enriched in the nucleus, and its level increases 10-fold after addition of staurosporine. The other gene pap1+ encodes an AP-1-like transcription factor that contains a region rich in basic amino acids followed by a "leucine zipper" motif. The pap1+ gene is required for spk1(+)-conferred staurosporine resistance. These two genes appear to function as a part of the fission yeast growth control pathway."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.5.1.60"xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.5.1.60"xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/author | "Shimanuki M."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/author | "Shimanuki M."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/author | "Toda T."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/pages | "60-73"xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/pages | "60-73"xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/title | "Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/title | "Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases."xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/1899230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1899230 |
| http://purl.uniprot.org/citations/1899230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1899230 |
| http://purl.uniprot.org/citations/1899230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1899230 |
| http://purl.uniprot.org/citations/1899230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1899230 |