| http://purl.uniprot.org/citations/18996084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18996084 | http://www.w3.org/2000/01/rdf-schema#comment | "Processing of antigens by proteases in the endocytic compartments of antigen presenting cells (APC) is essential to make them suitable for presentation as antigenic peptides to T lymphocytes. Several proteases of the cysteine, aspartyl and serine classes are involved in this process. It has been speculated, that the aspartyl protease cathepsin E (CatE) is involved in antigen processing in B cell line, monocyte-derived dendritic cells (DC) and murine DC. Here we show the expression of CatE in primary human B cells and DC, which was only elevated in B cells after induction with phorbol 12-myristate 13-acetate (PMA), resulted in enhanced presentation of tetanus toxin C-fragment (TTC) to the respective T cells. Inhibition of aspartyl proteases using pepstatin-A-penetratin (PepA-P), a highly efficient, cell-permeable aspartyl protease inhibitor, reduced significantly T cell activation in PMA activated B cells but not in PMA activated myeloid DC (mDC). Thus we suggest that CatE is important in the processing of TTC in primary human B cells."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.10.162"xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/author | "Voelter W."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/author | "Reich M."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/author | "Kalbacher H."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/author | "Zaidi N."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/author | "Burster T."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/author | "Boehm B.O."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/pages | "1299-1303"xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/title | "Cathepsin E regulates the presentation of tetanus toxin C-fragment in PMA activated primary human B cells."xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://purl.uniprot.org/core/volume | "377"xsd:string |
| http://purl.uniprot.org/citations/18996084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18996084 |
| http://purl.uniprot.org/citations/18996084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18996084 |
| http://purl.uniprot.org/uniprot/#_P14091-mappedCitation-18996084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18996084 |
| http://purl.uniprot.org/uniprot/#_A0A7P0MPN9-mappedCitation-18996084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18996084 |
| http://purl.uniprot.org/uniprot/#_B4DNU8-mappedCitation-18996084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18996084 |
| http://purl.uniprot.org/uniprot/P14091 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18996084 |
| http://purl.uniprot.org/uniprot/B4DNU8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18996084 |
| http://purl.uniprot.org/uniprot/A0A7P0MPN9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18996084 |