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http://purl.uniprot.org/citations/18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18996470http://www.w3.org/2000/01/rdf-schema#comment"Polymorphisms (rs1801282, rs8192678, rs7903146) of peroxisome proliferator-activated receptor gamma (PPARG), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) and transcription factor 7-like 2 (TCF7L2) have recently been associated with different diseases, mainly type 2 diabetes. An assay using unlabeled probes and the LightCycler or Rotor-Gene instruments was developed for genotyping of these three polymorphisms. Asymmetric polymerase chain reaction was used, followed by melting analysis of the unlabeled probe/ssDNA amplicon duplex. Samples with the target genotypes were accurately detected and easily distinguishable. Thus, genotyping using unlabeled probes is a rapid, accurate and cost effective closed-tube method. These assays demonstrated 100% specificity and sensitivity for the identification of selected polymorphisms in PPARG, PPARGC1A and TCF7L2 genes."xsd:string
http://purl.uniprot.org/citations/18996470http://purl.org/dc/terms/identifier"doi:10.1016/j.mcp.2008.10.001"xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/author"Habalova V."xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/author"Klimcakova L."xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/author"Tkac I."xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/author"Zidzik J."xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/name"Mol Cell Probes"xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/pages"52-54"xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/title"Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes."xsd:string
http://purl.uniprot.org/citations/18996470http://purl.uniprot.org/core/volume"23"xsd:string
http://purl.uniprot.org/citations/18996470http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/18996470
http://purl.uniprot.org/citations/18996470http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/18996470
http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_E9PFV2-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A0S2Z4K5-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A3P3ZKM0-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A2Z5HTN9-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_A0A494C1F9-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470
http://purl.uniprot.org/uniprot/#_B4DJZ2-mappedCitation-18996470http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/18996470