http://purl.uniprot.org/citations/18996470 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/18996470 | http://www.w3.org/2000/01/rdf-schema#comment | "Polymorphisms (rs1801282, rs8192678, rs7903146) of peroxisome proliferator-activated receptor gamma (PPARG), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) and transcription factor 7-like 2 (TCF7L2) have recently been associated with different diseases, mainly type 2 diabetes. An assay using unlabeled probes and the LightCycler or Rotor-Gene instruments was developed for genotyping of these three polymorphisms. Asymmetric polymerase chain reaction was used, followed by melting analysis of the unlabeled probe/ssDNA amplicon duplex. Samples with the target genotypes were accurately detected and easily distinguishable. Thus, genotyping using unlabeled probes is a rapid, accurate and cost effective closed-tube method. These assays demonstrated 100% specificity and sensitivity for the identification of selected polymorphisms in PPARG, PPARGC1A and TCF7L2 genes."xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcp.2008.10.001"xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/author | "Habalova V."xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/author | "Klimcakova L."xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/author | "Tkac I."xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/author | "Zidzik J."xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/name | "Mol Cell Probes"xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/pages | "52-54"xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/title | "Rapid and cost effective genotyping method for polymorphisms in PPARG, PPARGC1 and TCF7L2 genes."xsd:string |
http://purl.uniprot.org/citations/18996470 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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