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http://purl.uniprot.org/citations/18996700http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18996700http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/18996700http://www.w3.org/2000/01/rdf-schema#comment"Extensive molecular modeling based on crystallographic data was used to aid the design of synthetic analogues of the fungicidal naturally occurring respiration inhibitors crocacins A and D, and an inhibitor binding model to the mammalian cytochrome bc(1) complex was constructed. Simplified analogues were made which showed high activity in a mitochondrial beef heart respiration assay, and which were also active against certain plant pathogens in glasshouse tests. A crystal structure was obtained of an analogue of crocacin D bound to the chicken heart cytochrome bc(1) complex, which validated the binding model and which confirmed that the crocacins are a new class of inhibitor of the cytochrome bc(1) complex."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.org/dc/terms/identifier"doi:10.1016/j.bmc.2008.10.030"xsd:string
http://purl.uniprot.org/citations/18996700http://purl.org/dc/terms/identifier"doi:10.1016/j.bmc.2008.10.030"xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Lee D.W."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Lee D.W."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Taylor A."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Taylor A."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Phillips J.E."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Phillips J.E."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Daldal F."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Daldal F."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Crowley P.J."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Crowley P.J."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Berry E.A."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Berry E.A."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Viner R."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Viner R."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Cromartie T."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Cromartie T."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Godfrey C.R."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/author"Godfrey C.R."xsd:string
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/18996700http://purl.uniprot.org/core/date"2008"xsd:gYear