| http://purl.uniprot.org/citations/18997792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18997792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18997792 | http://www.w3.org/2000/01/rdf-schema#comment | "The adaptor and signaling proteins TRAF2, TRAF3, cIAP1 and cIAP2 may inhibit alternative nuclear factor-kappaB (NF-kappaB) signaling in resting cells by targeting NF-kappaB-inducing kinase (NIK) for ubiquitin-dependent degradation, thus preventing processing of the NF-kappaB2 precursor protein p100 to release p52. However, the respective functions of TRAF2 and TRAF3 in NIK degradation and activation of alternative NF-kappaB signaling have remained elusive. We now show that CD40 or BAFF receptor activation result in TRAF3 degradation in a cIAP1-cIAP2- and TRAF2-dependent way owing to enhanced cIAP1, cIAP2 TRAF3-directed ubiquitin ligase activity. Receptor-induced activation of cIAP1 and cIAP2 correlated with their K63-linked ubiquitination by TRAF2. Degradation of TRAF3 prevented association of NIK with the cIAP1-cIAP2-TRAF2 ubiquitin ligase complex, which resulted in NIK stabilization and NF-kappaB2-p100 processing. Constitutive activation of this pathway causes perinatal lethality and lymphoid defects."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1678"xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1678"xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Karin M."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Matsuzawa A."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Tseng P.H."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Tseng P.H."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Bergsagel P.L."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Bergsagel P.L."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Keats J.J."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Keats J.J."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Vallabhapurapu S."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/author | "Vallabhapurapu S."xsd:string |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18997792 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |