| http://purl.uniprot.org/citations/18997814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18997814 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation-induced cytidine deaminase (AID), the only enzyme that is known to be able to induce mutations in the human genome, is required for somatic hypermutation and class-switch recombination in B lymphocytes. Recently, we showed that AID is implicated in the pathogenesis of human cancers including hepatitis C virus (HCV)-induced human hepatocellular carcinoma (HCC). In this study, we established a new AID transgenic mouse model (TNAP-AID) in which AID is expressed in cells producing tissue-nonspecific alkaline phosphatase (TNAP), which is a marker of primordial germ cells and immature stem cells, including ES cells. High expression of TNAP was found in the liver of the embryos and adults of TNAP-AID mice. HCC developed in 27% of these mice at the age of approximately 90 weeks. The HCC that developed in TNAP-AID mice expressed alpha-fetoprotein and had deleterious mutations in the tumour suppressor gene Trp53, some of which corresponded to those found in human cancer. In conclusion, TNAP-AID is a mouse model that spontaneously develops HCC, sharing genetic and phenotypic features with human HCC, which develops in the inflamed liver as a result of the accumulation of genetic changes."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2008.415"xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Kinoshita K."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Honjo T."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Toyoshima T."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Kitawaki Y."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Okazaki I.M."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Takai A."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Uemura M."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Marusawa H."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/author | "Hiai H."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/pages | "469-478"xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/title | "A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations."xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/18997814 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18997814 |
| http://purl.uniprot.org/citations/18997814 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18997814 |
| http://purl.uniprot.org/uniprot/#_E0CXQ9-mappedCitation-18997814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18997814 |
| http://purl.uniprot.org/uniprot/#_E9Q7P8-mappedCitation-18997814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18997814 |
| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-18997814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18997814 |
| http://purl.uniprot.org/uniprot/#_B7XGA6-mappedCitation-18997814 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18997814 |