| http://purl.uniprot.org/citations/19000825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19000825 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the mechanism of kinesin13-induced microtubule depolymerization, we have calculated a three-dimensional (3D) map of the kinesin13-microtubule ring complex, using cryo-electron microscopy (cryo-EM) and image analysis. An atomic model of the complex was produced by docking the crystal structures of tubulin and a kinesin13 motor domain (MD) into the 3D map. The model reveals a snapshot of the depolymerization mechanism by providing a 3D view of the complex formed between the kinesin13 MD and a curved tubulin protofilament (pf). It suggests that contacts mediated by kinesin13 class-specific residues in the putative microtubule-binding site stabilize intra-dimer tubulin curvature. In addition, a tubulin-binding site on the kinesin13 MD was identified. Mutations at this class-conserved site selectively disrupt the formation of microtubule-associated ring complexes."xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2008.08.017"xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/author | "Tan D."xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/author | "Rice W.J."xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/author | "Sosa H."xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/pages | "1732-1739"xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/title | "Structure of the kinesin13-microtubule ring complex."xsd:string |
| http://purl.uniprot.org/citations/19000825 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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