| http://purl.uniprot.org/citations/19000841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19000841 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19000841 | http://www.w3.org/2000/01/rdf-schema#comment | "Ryk is a transmembrane receptor tyrosine kinase (RTK). It functions as a receptor of Wnt proteins required for cell-fate determination, axon guidance, and neurite outgrowth in different organisms; however, the molecular mechanism of Ryk signaling is unknown. Here, we show that Ryk is cleaved, permitting the intracellular C-terminal fragment of Ryk to translocate to the nucleus in response to Wnt3 stimulation. We also show that the cleaved intracellular domain of Ryk is required for Wnt3-induced neuronal differentiation in vitro and in vivo. These results demonstrate an unexpected mechanism of signal transduction for Ryk as a Wnt receptor, in which the intracellular domain itself functions as the transducing molecule to bring extracellular signals from the cell surface into the nucleus, to regulate neural progenitor cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2008.10.004"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2008.10.004"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/author | "Lyu J."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/author | "Lyu J."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/author | "Yamamoto V."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/author | "Yamamoto V."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/pages | "773-780"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/pages | "773-780"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/title | "Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/title | "Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis."xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/19000841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19000841 |
| http://purl.uniprot.org/citations/19000841 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19000841 |
| http://purl.uniprot.org/citations/19000841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19000841 |
| http://purl.uniprot.org/citations/19000841 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19000841 |