| http://purl.uniprot.org/citations/19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19001138 | http://www.w3.org/2000/01/rdf-schema#comment | "CD45 and Fas regulate tyrosine phosphorylation and apoptotic signaling pathways, respectively. Mutation of an inhibitory wedge motif in CD45 (E613R) results in hyperresponsive thymocytes and B cells on the C57BL/6 background, but no overt autoimmunity, whereas Fas deletion results in a mild autoimmune disease on the same genetic background. In this study, we show that these two mutations cooperate in mice, causing early lethality, autoantibody production, and substantial lymphoproliferation. In double-mutant mice, this phenotype was dependent on both T and B cells. T cell activation required signaling in response to endogenous or commensal antigens, demonstrated by the introduction of a transgenic T cell receptor. Genetic deletion of B cells also prevented T cell activation. Similarly, T cells were necessary for B cell autoantibody production. However, B cells appeared to be intrinsically activated even in the absence of T cells, suggesting that they may drive the phenotype of these mice. These results reveal a requirement for careful control of B cell signaling and cell death in preventing inappropriate lymphocyte activation and autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20081204"xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/author | "Gupta V.A."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/author | "Weiss A."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/author | "Daikh D.I."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/author | "Hermiston M.L."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/author | "Cassafer G."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/pages | "2755-2761"xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/title | "B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency."xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://purl.uniprot.org/core/volume | "205"xsd:string |
| http://purl.uniprot.org/citations/19001138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19001138 |
| http://purl.uniprot.org/citations/19001138 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19001138 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_A1E2H6-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_A0A494BBE8-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_A0A494BBP5-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_A1Y9B2-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_Q05C79-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_Q64730-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_P01029-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |
| http://purl.uniprot.org/uniprot/#_P06800-mappedCitation-19001138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001138 |