| http://purl.uniprot.org/citations/19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19001415 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon DNA damage, p53 can induce either cell-cycle arrest or apoptosis. Here we show that monocytic leukemia zinc finger (MOZ) forms a complex with p53 to induce p21 expression and cell-cycle arrest. The levels of the p53-MOZ complex increased in response to DNA damage to levels that induce cell-cycle arrest. MOZ(-/-) mouse embryonic fibroblasts failed to arrest in G1 in response to DNA damage, and DNA damage-induced expression of p21 was impaired in MOZ(-/-) cells. These results suggest that MOZ is involved in regulating cell-cycle arrest in the G1 phase. Screening of tumor-associated p53 mutants demonstrated that the G279E mutation in p53 disrupts interactions between p53 and MOZ, but does not affect the DNA binding activity of p53. The leukemia-associated MOZ-CBP fusion protein inhibits p53-mediated transcription. These results suggest that inhibition of p53/MOZ-mediated transcription is involved in tumor pathogenesis and leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m805101200"xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/author | "Taya Y."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/author | "Tsuchida N."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/author | "Aikawa Y."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/author | "Kitabayashi I."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/author | "Rokudai S."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/author | "Tagata Y."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/pages | "237-244"xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/title | "Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest."xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19001415 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19001415 |
| http://purl.uniprot.org/citations/19001415 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A087X1Q1-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A0C4KX50-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A0C4L134-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A218MJE5-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A087WT22-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A0A0U7X4-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |
| http://purl.uniprot.org/uniprot/#_A0A346XLN8-mappedCitation-19001415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19001415 |