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http://purl.uniprot.org/citations/19003637http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19003637http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To test the hypothesis that vascular endothelial growth factor receptor 1 (Flt1) is negatively correlated with apoptosis in preeclampsia placentae, and to examine the effects of antihypertensive medication on apoptosis.

Methods

Flt1 and TUNEL immunoreactivity were quantitatively compared in the stromal decidual cells, villous trophoblasts, and endothelial cells of placentae from uncomplicated pregnancies (NP, n = 34) to those in patients with preeclampsia (PE, n = 30), and those in patients with preeclampsia with superimposed intrauterine growth restriction (PE + IUGR, n = 7). Further analyses determined any correlations with the antepartum use of the antihypertensives clonidine and hydralazine.

Results

There was no difference in either Flt1 or TUNEL when comparing PE placentae (with or without IUGR) with NP. There were no correlations with the use of the antihypertensives.

Conclusion

Apoptotic levels do not correlate with Flt1 in preeclampsia placentae and are not regulated by in vivo exposure to the antihypertensives clonidine and hydralazine."xsd:string
http://purl.uniprot.org/citations/19003637http://purl.org/dc/terms/identifier"doi:10.1080/10641950802020552"xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/author"Thornton C."xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/author"Makris A."xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/author"Hennessy A."xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/author"Machaalani R."xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/name"Hypertens Pregnancy"xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/pages"361-373"xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/title"Vascular endothelial growth factor receptor 1 (Flt1) and apoptosis in the preeclamptic placenta and effects of in vivo anti-hypertensive exposure."xsd:string
http://purl.uniprot.org/citations/19003637http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/19003637http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19003637
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