| http://purl.uniprot.org/citations/19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19003818 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of NKT cells was shown to depend on lymphotoxin (LT) and IL-15 signaling pathways as well as on cytokine receptor common gamma chain. After positive selection, NKT-cell precursors transit through progressive maturation stages including proliferative expansion within the NK1.1(-) window. The transcription factors that integrate different signaling pathways into different stages of NKT-cell development are not well characterized. Here, we show that the Rel/NF-kappaB family member RelA regulates the NK1.1(-) to NK1.1(+) transition during NKT-cell development. RelA is also required for both IL-15- and IL-7-induced proliferation of CD44(hi)NK1.1(-) NKT-cell precursors. Activation of the invariant NKT-cell receptor induces both IL-15 receptor alpha and gamma chains' expression in an NF-kappaB-dependent manner, suggesting a molecular mechanism by which NF-kappaB regulates NKT-cell development. NF-kappaB also regulates TCR-induced expression of LT-alpha and LT-beta within NKT cells. In contrast to previous reports, however, we show that LT signaling is dispensable for thymic NKT-cell development but is essential for their colonization of peripheral organs such as liver."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737830"xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Riemann M."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Pfeffer K."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Korner H."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Schmid R.M."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Weih F."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Paxian S."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Vallabhapurapu S."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/author | "Powolny-Budnicka I."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/pages | "3508-3519"xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/title | "Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells."xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/19003818 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19003818 |
| http://purl.uniprot.org/citations/19003818 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19003818 |
| http://purl.uniprot.org/uniprot/#_P15307-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |
| http://purl.uniprot.org/uniprot/#_A0A494B901-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |
| http://purl.uniprot.org/uniprot/#_A0A0U5J4W4-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA2-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA8-mappedCitation-19003818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19003818 |