| http://purl.uniprot.org/citations/19004760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19004760 | http://www.w3.org/2000/01/rdf-schema#comment | "Our conditional serum response factor (SRF) knockout, Srf (Cko), in the heart-forming region blocked the appearance of rhythmic beating myocytes, one of the earliest cardiac defects caused by the ablation of a cardiac-enriched transcription factor. The appearance of Hand1 and Smyd1, transcription and chromatin remodeling factors; Acta1, Acta2, Myl3, and Myom1, myofibril proteins; and calcium-activated potassium-channel gene activity (KCNMB1), the channel protein, were powerfully attenuated in the Srf(CKO) mutant hearts. A requisite role for combinatorial cofactor interactions with SRF, as a major determinant for regulating the appearance of organized sarcomeres, was shown by viral rescue of SRF-null ES cells with SRF point mutants that block cofactor interactions. In the absence of SRF genes associated with biomineralization, GATA-6, bone morphogenetic protein 4 (BMP4), and periostin were strongly up-regulated, coinciding with the down regulation of many SRF dependent microRNA, including miR1, which exerted robust silencer activity over the induction of GATA-6 leading to the down regulation of BMP4 and periostin."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0805491105"xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Martin J.F."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Nordheim A."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Srivastava D."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Conway S.J."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Schwartz R.J."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Niu Z."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Ivey K."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/author | "Iyer D."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/pages | "17824-17829"xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/title | "Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart."xsd:string |
| http://purl.uniprot.org/citations/19004760 | http://purl.uniprot.org/core/volume | "105"xsd:string |
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