| http://purl.uniprot.org/citations/19004835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19004835 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19004835 | http://www.w3.org/2000/01/rdf-schema#comment | "Thrombospondin-1 regulates nitric oxide (NO) signaling in vascular cells via CD47. Because CD47 binding motifs are conserved in the C-terminal signature domains of all five thrombospondins and indirect evidence has implied CD47 interactions with other family members, we compared activities of recombinant signature domains of thrombospondin-1, -2, and -4 to interact with CD47 and modulate cGMP signaling. Signature domains of thrombospondin-2 and -4 were less active than that of thrombospondin-1 for inhibiting binding of radiolabeled signature domain of thrombospondin-1 or SIRPalpha (signal-regulatory protein) to cells expressing CD47. Consistent with this binding selectivity, the signature domain of thrombospondin-1 was more potent than those of thrombospondin-2 or -4 for inhibiting NO-stimulated cGMP synthesis in vascular smooth muscle cells and downstream effects on cell adhesion. In contrast to thrombospondin-1- and CD47-null cells, primary vascular cells from thrombospondin-2-null mice lack enhanced basal and NO-stimulated cGMP signaling. Effects of endogenous thrombospondin-2 on NO/cGMP signaling could be detected only in thrombospondin-1-null cells. Furthermore, tissue survival of ischemic injury and acute recovery of blood flow in thrombospondin-2-nulls resembles that of wild type mice. Therefore, thrombospondin-1 is the dominant regulator of NO/cGMP signaling via CD47, and its limiting role in acute ischemic injury responses is not shared by thrombospondin-2."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m804860200"xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m804860200"xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Pendrak M.L."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Pendrak M.L."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Frazier W.A."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Frazier W.A."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Mosher D.F."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Mosher D.F."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Roberts D.D."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Roberts D.D."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Annis D.S."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Annis D.S."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Isenberg J.S."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Isenberg J.S."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Ptaszynska M."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/author | "Ptaszynska M."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/pages | "1116-1125"xsd:string |
| http://purl.uniprot.org/citations/19004835 | http://purl.uniprot.org/core/pages | "1116-1125"xsd:string |