| http://purl.uniprot.org/citations/19004955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19004955 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-15 (IL-15) is necessary for the development and function of NK/NKT cells and the maintenance of naive and memory CD8(+) T cells. In the absence of IL-15, protective innate immunity is not available; however, a functional adaptive immune response against vaginal herpes simplex virus 2 (HSV-2) is generated. Mice overexpressing IL-15 (IL-15tg mice) have higher numbers of NK cells, greater NK-derived gamma interferon, and more CD8(+) T cells. Here we examined the consequences of IL-15 overexpression for innate and adaptive immunity against genital HSV-2. Surprisingly, IL-15tg mice immunized against HSV-2 were not protected against genital HSV-2 challenge compared to control immunized mice. IL-15tg mice had a higher frequency of NK cells in the genital mucosa than control mice. However, immunized IL-15tg mice had significantly lower numbers of HSV-2-specific CD4(+) T cells than B6 mice. We then confirmed that CD4(+) T cells, but not CD8(+) T cells, are essential for protection against intravaginal HSV-2 challenge. Since we observed less protection in immunized IL-15tg mice, we then examined if the adaptive immune responses generated in an environment with overexpression of IL-15 could provide protection against HSV-2 in an environment with normal levels of IL-15 expression. We adoptively transferred immunized cells from IL-15tg and B6 mice into naive RAG-1(-/-) mice and found that the cells from immunized IL-15tg mice were able to provide protection in this IL-15-normal environment. Our data suggest that overexpression of IL-15 results in a reduced CD4(+) T cell-mediated adaptive immune response against genital HSV-2."xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01282-08"xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/author | "Gill N."xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/author | "Ashkar A.A."xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/pages | "918-926"xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/title | "Overexpression of interleukin-15 compromises CD4-dependent adaptive immune responses against herpes simplex virus 2."xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/19004955 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19004955 |
| http://purl.uniprot.org/citations/19004955 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19004955 |
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| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-19004955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19004955 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ7-mappedCitation-19004955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19004955 |
| http://purl.uniprot.org/uniprot/#_P48346-mappedCitation-19004955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19004955 |
| http://purl.uniprot.org/uniprot/#_Q3U1Z6-mappedCitation-19004955 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19004955 |
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| http://purl.uniprot.org/uniprot/Q1AHQ7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19004955 |