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http://purl.uniprot.org/citations/19005011http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19005011http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19005011http://www.w3.org/2000/01/rdf-schema#comment"Myosin 1e (Myo1e) is one of two Src homology 3 domain-containing "long-tailed" type I myosins in vertebrates, whose functions in health and disease are incompletely understood. Here, we demonstrate that Myo1e localizes to podocytes in the kidney. We generated Myo1e-knockout mice and found that they exhibit proteinuria, signs of chronic renal injury, and kidney inflammation. At the ultrastructural level, renal tissue from Myo1e-null mice demonstrates changes characteristic of glomerular disease, including a thickened and disorganized glomerular basement membrane and flattened podocyte foot processes. These observations suggest that Myo1e plays an important role in podocyte function and normal glomerular filtration."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.org/dc/terms/identifier"doi:10.1681/asn.2007111172"xsd:string
http://purl.uniprot.org/citations/19005011http://purl.org/dc/terms/identifier"doi:10.1681/asn.2007111172"xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Krendel M."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Krendel M."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Wang T."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Wang T."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Flavell R.A."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Flavell R.A."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Mooseker M.S."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Mooseker M.S."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Kashgarian M."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Kashgarian M."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Kim S.V."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Kim S.V."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Willinger T."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/author"Willinger T."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/name"J. Am. Soc. Nephrol."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/name"J. Am. Soc. Nephrol."xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/pages"86-94"xsd:string
http://purl.uniprot.org/citations/19005011http://purl.uniprot.org/core/pages"86-94"xsd:string