| http://purl.uniprot.org/citations/19007774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19007774 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19007774 | http://www.w3.org/2000/01/rdf-schema#comment | "Rod photoreceptors are highly polarized cells whose exquisite sensitivity to light depends on precise compartmentalization of ion channels/transporters within specialized membrane domains. Here, we report evidence for an ankyrin-B based mechanism for coordinated expression of the beta-2-spectrin-based membrane skeleton, and the Na/K-ATPase and Na/Ca exchanger in the inner segment of rod photoreceptors. We first discovered that ankyrin-B localizes to the inner segments but not outer segments of rod photoreceptors in vertebrates including humans, mice, and frogs. We found that haploinsufficiency of ankyrin-B in mice is accompanied by 50% reduction in inner segments of membrane proteins, including the Na/K-ATPase and the Na/Ca exchanger, as well as beta-2-spectrin, which is a component of the spectrin-actin membrane skeleton. These results are consistent with a mechanism where ankyrin-B is required to restrict the Na/K-ATPase and Na/Ca exchanger to the inner segment of rod photoreceptors by tethering these membrane proteins to beta-2-spectrin."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exer.2008.09.022"xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exer.2008.09.022"xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Bennett V."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Bennett V."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Kizhatil K."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Kizhatil K."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Peachey N.S."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Peachey N.S."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Sandhu N.K."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/author | "Sandhu N.K."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/name | "Exp. Eye Res."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/name | "Exp. Eye Res."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/pages | "57-64"xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/pages | "57-64"xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/title | "Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/title | "Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors."xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/19007774 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19007774 |
| http://purl.uniprot.org/citations/19007774 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19007774 |