| http://purl.uniprot.org/citations/19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19008226 | http://www.w3.org/2000/01/rdf-schema#comment | "Lumican and fibromodulin compete for collagen type I binding in vitro, and fibromodulin-deficient mice have 4-fold more lumican in tendons. These observations indicate that homologous sequences in lumican and fibromodulin bind to collagen type I. Here, we demonstrate that lumican binding to collagen type I is mediated mainly by Asp-213 in leucine-rich repeat (LRR) 7. The mutation D213N in lumican impairs interaction with collagen, and the lumican fragment spanning LRRs 5-7 is an efficient inhibitor of collagen binding. Also, the lumican LRR 7 sequence-based synthetic peptide CYLDNNKC inhibits the binding to collagen. Homologous collagen-binding site in fibromodulin, located in LRRs 5-7, inhibits the binding of lumican to collagen, and the mutation E251Q in this fibromodulin fragment does not inhibit the lumican-collagen binding. Lumican, but not the D213N mutation, lowers the melting point and affects the packing of collagen fibrils."xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m805721200"xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/author | "Kalamajski S."xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/author | "Oldberg A."xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/pages | "534-539"xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/title | "Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding."xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19008226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19008226 |
| http://purl.uniprot.org/citations/19008226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19008226 |
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| http://purl.uniprot.org/uniprot/#_A0A384N669-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
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| http://purl.uniprot.org/uniprot/#_B3KYB3-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
| http://purl.uniprot.org/uniprot/#_B4E1J3-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
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| http://purl.uniprot.org/uniprot/#_Q06828-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
| http://purl.uniprot.org/uniprot/#_Q12833-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
| http://purl.uniprot.org/uniprot/#_P50608-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
| http://purl.uniprot.org/uniprot/#_Q8BNU3-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
| http://purl.uniprot.org/uniprot/#_Q7TPZ1-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |
| http://purl.uniprot.org/uniprot/#_Q53FV4-mappedCitation-19008226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19008226 |