| http://purl.uniprot.org/citations/19010391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19010391 | http://www.w3.org/2000/01/rdf-schema#comment | "The p62 protein has been identified as a major component of the protein aggregations associated with neurodegenerative disease. Oxidative insult has also been identified as a principal cause of neurodegenerative disease. Thus, in the present study, we investigated the potential role of p62 in oxidative stress-induced cell death in SH-SY5Y human neuroblastoma cells. The results indicated that H(2)O(2) treatment induced p62 expression in SH-SY5Y cells. In addition, p62 showed neuroprotective effects against H(2)O(2)-induced cell death in differentiated SH-SY5Y cells. p62 expression prolonged Akt phosphorylation during the later stages of H(2)O(2)-induced cell death. Furthermore, coexpression of p62 and wild-type PDK1, the upstream kinase of Akt, further increased Akt phosphorylation and cell viability, whereas the expression of kinase-defective PDK1 reversed the cytoprotective effects of p62 under oxidative stress. Overexpression of p62 led to the dissociation of PDK1 from the 14-3-3theta protein, which is thought to be a negative regulator of PDK1 kinase activity. These findings suggest a mechanism that involves the p62-mediated modulation of the interaction between signaling molecules and results in cell survival."xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2008.11.011"xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/author | "Kwon Y.K."xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/author | "Joung I."xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/author | "Han A.M."xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/author | "Heo S.R."xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/pages | "45-50"xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/title | "p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway."xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://purl.uniprot.org/core/volume | "450"xsd:string |
| http://purl.uniprot.org/citations/19010391 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19010391 |
| http://purl.uniprot.org/citations/19010391 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19010391 |
| http://purl.uniprot.org/uniprot/#_B4DE82-mappedCitation-19010391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19010391 |
| http://purl.uniprot.org/uniprot/#_B4E3V2-mappedCitation-19010391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19010391 |
| http://purl.uniprot.org/uniprot/#_Q13501-mappedCitation-19010391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19010391 |
| http://purl.uniprot.org/uniprot/B4DE82 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19010391 |
| http://purl.uniprot.org/uniprot/B4E3V2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19010391 |
| http://purl.uniprot.org/uniprot/Q13501 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19010391 |