| http://purl.uniprot.org/citations/19010779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19010779 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19010779 | http://www.w3.org/2000/01/rdf-schema#comment | "The Hermansky-Pudlak syndrome is a disorder affecting endosome sorting. Disease is triggered by defects in any of 15 mouse gene products, which are part of five distinct cytosolic molecular complexes: AP-3, homotypic fusion and vacuole protein sorting, and BLOC-1, -2, and -3. To identify molecular associations of these complexes, we used in vivo cross-linking followed by purification of cross-linked AP-3 complexes and mass spectrometric identification of associated proteins. AP-3 was co-isolated with BLOC-1, BLOC-2, and homotypic fusion and vacuole protein sorting complex subunits; clathrin; and phosphatidylinositol-4-kinase type II alpha (PI4KIIalpha). We previously reported that this membrane-anchored enzyme is a regulator of AP-3 recruitment to membranes and a cargo of AP-3 ( Craige, B., Salazar, G., and Faundez, V. (2008) Mol. Biol. Cell 19, 1415-1426 ). Using cells deficient in different Hermansky-Pudlak syndrome complexes, we identified that BLOC-1, but not BLOC-2 or BLOC-3, deficiencies affect PI4KIIalpha inclusion into AP-3 complexes. BLOC-1, PI4KIIalpha, and AP-3 belong to a tripartite complex, and down-regulation of either PI4KIIalpha, BLOC-1, or AP-3 complexes led to similar LAMP1 phenotypes. Our analysis indicates that BLOC-1 complex modulates the association of PI4KIIalpha with AP-3. These results suggest that AP-3 and BLOC-1 act, either in concert or sequentially, to specify sorting of PI4KIIalpha along the endocytic route."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m805991200"xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m805991200"xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Pohl J."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Pohl J."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Peden A.A."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Peden A.A."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Salazar G."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Salazar G."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Craige B."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Craige B."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Zlatic S."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/author | "Zlatic S."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/pages | "1790-1802"xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/pages | "1790-1802"xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/title | "Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/19010779 | http://purl.uniprot.org/core/title | "Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells."xsd:string |