| http://purl.uniprot.org/citations/19011221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19011221 | http://www.w3.org/2000/01/rdf-schema#comment | "GATA-1 controls hematopoietic development by activating and repressing gene transcription, yet the in vivo mechanisms that specify these opposite activities are unknown. By examining the composition of GATA-1-associated protein complexes in a conditional erythroid rescue system as well as through the use of tiling arrays we detected the SCL/TAL1, LMO2, Ldb1, E2A complex at all positively acting GATA-1-bound elements examined. Similarly, the SCL complex is present at all activating GATA elements in megakaryocytes and mast cells. In striking contrast, at sites where GATA-1 functions as a repressor, the SCL complex is depleted. A DNA-binding defective form of SCL maintains association with a subset of active GATA elements indicating that GATA-1 is a key determinant for SCL recruitment. Knockdown of LMO2 selectively impairs activation but not repression by GATA-1. ETO-2, an SCL-associated protein with the potential for transcription repression, is also absent from GATA-1-repressed genes but, unlike SCL, fails to accumulate at GATA-1-activated genes. Together, these studies identify the SCL complex as a critical and consistent determinant of positive GATA-1 activity in multiple GATA-1-regulated hematopoietic cell lineages."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-07-169417"xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Deng W."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Hardison R.C."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Blobel G.A."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Vakoc C.R."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Tripic T."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/author | "Gregory G.D."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/pages | "2191-2201"xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/title | "SCL and associated proteins distinguish active from repressive GATA transcription factor complexes."xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/19011221 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19011221 |
| http://purl.uniprot.org/citations/19011221 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19011221 |
| http://purl.uniprot.org/uniprot/P17679#attribution-8218C15C0DC9BFF5E102B086E8F9C507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19011221 |
| http://purl.uniprot.org/uniprot/P70662#attribution-8218C15C0DC9BFF5E102B086E8F9C507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19011221 |
| http://purl.uniprot.org/uniprot/P25801#attribution-0EE1BD49681B33C0313F65B159542594 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19011221 |
| http://purl.uniprot.org/uniprot/P25801#attribution-8218C15C0DC9BFF5E102B086E8F9C507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19011221 |
| http://purl.uniprot.org/uniprot/P22091#attribution-8218C15C0DC9BFF5E102B086E8F9C507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19011221 |
| http://purl.uniprot.org/uniprot/P15806#attribution-8218C15C0DC9BFF5E102B086E8F9C507 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19011221 |
| http://purl.uniprot.org/uniprot/#_D3Z1C5-mappedCitation-19011221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19011221 |