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http://purl.uniprot.org/citations/19013515http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19013515http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19013515http://www.w3.org/2000/01/rdf-schema#comment"In the nervous system the Liprin-alpha protein family plays an important role in the regulation of dendrite development, the targeting of photoreceptor axons, and the formation and structure of synapses. To gain a better understanding of Liprin-alpha regulation we have comparatively analyzed the genomic organization of the human and mouse Liprin-alpha genes, characterized the alternative exon use in human and mouse, and studied their expression in adult rodent tissues and brain regions. Our results show that Liprins-alpha1-4 share multiple properties in their genomic structure, exhibit an identical modular organization, and are highly conserved within certain structural domains, indicating strong evolutionary cohesion. We demonstrate that all Liprin-alpha genes are subject to alternative splicing, which is regulated in a developmental manner. Interestingly, regulation via alternative splicing is not conserved between isoforms and across species and represents a post-transcriptional mechanism to independently diversify the properties of the individual isoforms."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.org/dc/terms/identifier"doi:10.1016/j.ygeno.2008.10.007"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.org/dc/terms/identifier"doi:10.1016/j.ygeno.2008.10.007"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/author"Schoch S."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/author"Schoch S."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/author"Zurner M."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/author"Zurner M."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/name"Genomics"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/name"Genomics"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/pages"243-253"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/pages"243-253"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/title"The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/title"The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing."xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/volume"93"xsd:string
http://purl.uniprot.org/citations/19013515http://purl.uniprot.org/core/volume"93"xsd:string
http://purl.uniprot.org/citations/19013515http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19013515
http://purl.uniprot.org/citations/19013515http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19013515
http://purl.uniprot.org/citations/19013515http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19013515
http://purl.uniprot.org/citations/19013515http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19013515
http://purl.uniprot.org/uniprot/B8QI34http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/19013515
http://purl.uniprot.org/uniprot/P60469http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/19013515