| http://purl.uniprot.org/citations/19015237 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19015237 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulation of mRNA transport is a fundamental process for cytoplasmic sorting of transcripts and spatially controlled translational derepression once properly localized. There is growing evidence that translation is locally modulated as a result of specific synaptic inputs. However, the underlying molecular mechanisms that regulate this translational process are just emerging. We show that KIS, a serine/threonine kinase functionally related to microtubule dynamics and axon development, interacts with three proteins found in RNA granules: KIF3A, NonO, and eEF1A. KIS localizes to RNA granules and colocalizes with the KIF3A kinesin and the beta-actin mRNA in cultured cortical neurons. In addition, KIS is found associated with KIF3A and 10 RNP-transported mRNAs in brain extracts. The results of knockdown experiments indicate that KIS is required for normal neurite outgrowth. More important, the kinase activity of KIS stimulates 3' untranslated region-dependent local translation in neuritic projections. We propose that KIS is a component of the molecular device that modulates translation in RNA-transporting granules as a result of local signals."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01180-08"xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/author | "Aldea M."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/author | "Gallego C."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/author | "Gari E."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/author | "Cambray S."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/author | "Pedraza N."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/author | "Rafel M."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/pages | "726-735"xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/title | "Protein kinase KIS localizes to RNA granules and enhances local translation."xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19015237 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19015237 |
| http://purl.uniprot.org/citations/19015237 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19015237 |
| http://purl.uniprot.org/uniprot/P97343#attribution-1D64F3688C83960D09DEEC8B6DDAA7DB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19015237 |
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