| http://purl.uniprot.org/citations/19015318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19015318 | http://www.w3.org/2000/01/rdf-schema#comment | "The active vitamin D metabolite 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a transcription factor of the nuclear receptor superfamily. Additionally, 1,25(OH)(2)D(3) has several nongenomic effects of uncertain relevance. We show that 1,25(OH)(2)D(3) induces a transcription-independent Ca(2+) influx and activation of RhoA-Rho-associated coiled kinase (ROCK). This requires VDR and is followed by activation of the p38 mitogen-activated protein kinase (p38MAPK) and mitogen- and stress-activated kinase 1 (MSK1). As shown by the use of chemical inhibitors, dominant-negative mutants and small interfering RNA, RhoA-ROCK, and p38MAPK-MSK1 activation is necessary for the induction of CDH1/E-cadherin, CYP24, and other genes and of an adhesive phenotype by 1,25(OH)(2)D(3). RhoA-ROCK and MSK1 are also required for the inhibition of Wnt-beta-catenin pathway and cell proliferation. Thus, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200803020"xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Munoz A."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Barbachano A."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Lafarga M."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Berciano M.T."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Dunach M."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Palmer H.G."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "de Herreros A.G."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Villalobos C."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Larriba M.J."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Ordonez-Moran P."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/author | "Valero R.A."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/pages | "697-710"xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/title | "RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/19015318 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19015318 |
| http://purl.uniprot.org/citations/19015318 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19015318 |
| http://purl.uniprot.org/uniprot/#_A0A024R324-mappedCitation-19015318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19015318 |
| http://purl.uniprot.org/uniprot/#_P61586-mappedCitation-19015318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19015318 |
| http://purl.uniprot.org/uniprot/#_A0A0B6XK12-mappedCitation-19015318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19015318 |
| http://purl.uniprot.org/uniprot/#_A0A345GP07-mappedCitation-19015318 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19015318 |