| http://purl.uniprot.org/citations/19016524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19016524 | http://www.w3.org/2000/01/rdf-schema#comment | "A proliferation-inducing ligand (APRIL or TNFSF13) shares receptors with B-cell activation factor of the TNF family (BAFF) on B and T cells. Although much is known about the function of APRIL in B cells, its role in T cells remains unclear. Blocking both BAFF and APRIL suggested that BAFF and/or APRIL contributed to collagen-induced arthritis (CIA); however, the role of APRIL alone in CIA remained unresolved. We show here that, in vitro, our newly generated APRIL(-/-) mice exhibited increased T-cell proliferation, enhanced Th2 cytokine production under non-polarizing conditions, and augmented IL-13 and IL-17 production under Th2 polarizing conditions. Upon immunization with OVA and aluminum potassium sulfate, APRIL(-/-) mice responded with an increased antigen-specific IgG1 response. We also show that in APRIL(-/-) mice, the incidence of CIA was significantly reduced compared with WT mice in parallel with diminished levels of antigen-specific IgG2a autoantibody and IL-17 production. Our data indicate that APRIL plays an important role in the regulation of cytokine production and that APRIL-triggered signals contribute to arthritis. Blockade of APRIL thus may be a valuable adjunct in the treatment of rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838640"xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/author | "Podack E.R."xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/author | "Motomura S."xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/pages | "3450-3458"xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/title | "APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response."xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/19016524 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19016524 |
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