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http://purl.uniprot.org/citations/19018513http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19018513http://www.w3.org/2000/01/rdf-schema#comment"

Aims/hypothesis

Common genetic variants influence plasma triacylglycerol, HDL-cholesterol (HDL-C) and glucose levels in cross-sectional studies. However, the longitudinal effects of these established variants have not been studied. Our aim was to examine the longitudinal associations of four such variants in the apolipoprotein A-V (APOA5), lipoprotein lipase (LPL), and glucokinase (GCK) genes with fasting glucose or lipid levels.

Methods

The individuals analysed were participants in the Busselton Health Survey (n = 4,554). Cross-sectional analyses of family data used the total association test. Longitudinal association analyses of unrelated participant data (n = 2,864) used linear mixed-effects models.

Results

The findings of cross-sectional association analyses replicated those of previous studies. We observed associations of the G and C alleles at the APOA5 single nucleotide polymorphisms (SNPs) rs662799 and rs3135506 with raised triacylglycerol levels (p = 0.0003 and p < 0.0001, respectively), the 447X allele at the LPL SNP rs328 with reduced triacylglycerol levels (p = 0.0004) and raised HDL-C levels (p = 0.0004), and the A allele of the GCK SNP rs1799884 with raised fasting glucose level (p = 0.015). Longitudinal association analyses showed that most of these associations did not change in the same individuals over an average follow-up time of 17.4 years, though there was some evidence that the association of the 447X allele of rs328 with raised HDL-C level significantly increased with age (p = 0.01), and that the association of the C allele of rs3135506 with raised triacylglycerol level significantly increased over time (p = 0.0007).

Conclusions/interpretation

The current study suggests that the effects of established gene variants on lipid and glucose traits do not tend to alter with age during adulthood or over time."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.org/dc/terms/identifier"doi:10.1007/s00125-008-1175-9"xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Hattersley A.T."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Frayling T.M."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Weedon M.N."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Beilby J.P."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"McCaskie P.A."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Palmer L.J."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Warrington N.M."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/author"Webster R.J."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/name"Diabetologia"xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/pages"106-114"xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/title"The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits."xsd:string
http://purl.uniprot.org/citations/19018513http://purl.uniprot.org/core/volume"52"xsd:string
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