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http://purl.uniprot.org/citations/19019335http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19019335http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The objective of the study was to study the genetic risk factors of spontaneous preterm birth (PTB) in African Americans.

Study design

Case-control analyses were performed using maternal and fetal deoxyribonucleic acid from 279 African American birth events (82 PTB and 197 term) and 1432 single-nucleotide polymorphisms from 130 candidate genes. Single-locus association and haplotype analyses were performed.

Results

The most significant associations were in the maternal interleukin (IL)-15 (rs10833, allele P = 2.91 x 10(-4), genotype P = 2.00 x 10(-3)) gene and the fetal IL-2 receptor B (IL-2RB) (rs84460, allele P = 1.37 x 10(-4), genotype P = 6.29 x 10(-4)) gene. The best models for these markers were additive (rs10833, odds ratio [OR], 0.30; 95% confidence interval [CI], 0.14-0.62; P = 1.0 x 10(-3); rs84460, OR, 2.32; 95% CI, 1.47-3.67; P < 1.0 x 10(-3)). The largest number of significant associations was found in genes related to infection and inflammation. There were overall a larger number of significant associations in infants than in mothers.

Conclusion

These results support a strong role for genes involved in infection and inflammation in the pathogenesis of PTB, particularly IL-12 and IL-12RB, and indicate that in African Americans there may be complementarity of maternal and fetal genetic risks for PTB."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.org/dc/terms/identifier"doi:10.1016/j.ajog.2008.08.051"xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/author"Williams S.M."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/author"Lombardi S.J."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/author"Menon R."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/author"Fortunato S."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/author"Thorsen P."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/author"Velez D.R."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/name"Am J Obstet Gynecol"xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/pages"209.e1-27"xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/title"Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants."xsd:string
http://purl.uniprot.org/citations/19019335http://purl.uniprot.org/core/volume"200"xsd:string
http://purl.uniprot.org/citations/19019335http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19019335
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