| http://purl.uniprot.org/citations/19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19020722 | http://www.w3.org/2000/01/rdf-schema#comment | "Ovarian carcinoma patients have an extremely poor prognosis; therefore, new molecular therapeutic approaches are urgently needed. The mTOR pathway, which may be targeted by substances such as Rapamycin or RAD001, is emerging as a promising target for anticancer therapy. So far, the expression and prognostic impact of mTOR signalling elements have not been completely studied in ovarian tumors. We analyzed p-mTOR, p-4E-BP1 and p-eIF-4E in 107 human ovarian lesions and observed an overexpression of p-mTOR (47%) and p-eIF-4E (56%) protein in primary ovarian carcinomas as compared to borderline tumors. Phospho-mTOR expression was significantly related to p-eIF-4E (p< or =0.001) and serous histological type (p=0.03). Increased p-4E-BP1 (31%) was associated with poor differentiation (p=0.04) and higher mitotic rate (p=0.004). In univariate analysis, increased expression of p-mTOR and p-eIF-4E was significantly associated with better overall survival (p=0.003, p=0.029). To connect the expression data with mechanistic studies, a set of 10 ovarian cancer cell lines was used. Expression of p-mTOR was increased in all cancer cell lines as compared to ovarian surface epithelial (HOSE) cells. Rapamycin treatment revealed a reduction of p-mTOR and p-4E-BP1 but increased p-AKT levels. We show for the first time an association of p-mTOR and p-eIF-4E with better overall survival for ovarian cancer patients. The combined results of our in vivo and cell culture studies suggest that a subpopulation of these patients may benefit from mTOR inhibition. The design of future clinical trials should incorporate biomarker testing to determine predictive markers for response to mTOR inhibitors."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Noske A."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Weichert W."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Dietel M."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Sehouli J."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Denkert C."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Buckendahl A.C."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Roske A."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Darb-Esfahani S."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/author | "Lindenberg J.L."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/pages | "1409-1417"xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/title | "Activation of mTOR in a subgroup of ovarian carcinomas: correlation with p-eIF-4E and prognosis."xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/19020722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19020722 |
| http://purl.uniprot.org/citations/19020722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19020722 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TQ52-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |
| http://purl.uniprot.org/uniprot/#_B4DZD5-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |
| http://purl.uniprot.org/uniprot/#_B3KX59-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |
| http://purl.uniprot.org/uniprot/#_B4E2H2-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |
| http://purl.uniprot.org/uniprot/#_B7Z2T1-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |
| http://purl.uniprot.org/uniprot/#_D6RBW1-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |
| http://purl.uniprot.org/uniprot/#_P42345-mappedCitation-19020722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19020722 |