| http://purl.uniprot.org/citations/19022959 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19022959 | http://www.w3.org/2000/01/rdf-schema#comment | "15,15'-carotenoid monooxygenase (CMO I) is generally recognized as the central carotenoid cleavage enzyme responsible for converting provitamin A carotenoids to vitamin A, while having little affinity for nonprovitamin A carotenoids, such as lycopene. To investigate the role of CMO I in carotenoid metabolism, approximately 90-d-old C57BL/6 x 129/SvJ [CMO I wild-type (WT)] and B6;129S6-Bcmo1tm1Dnp [CMO I knockout (KO)] mice were fed a high-fat, moderate vitamin A, cholesterol-containing diet supplemented with 150 mg/kg diet of beta-carotene, lycopene, or placebo beadlets for 60 d (n = 12-14). CMO I KO mice fed lycopene (Lyc-KO) exhibited significant decreases in hepatic, spleen, and thymus lycopene concentrations and significant increases in prostate, seminal vesicles, testes, and brain lycopene concentrations compared with WT mice fed lycopene (Lyc-WT). Furthermore, in the serum and all tissues analyzed, excluding the testes, there was a significant increase in the percent lycopene cis isomers in Lyc-KO mice compared with Lyc-WT mice. CMO I KO mice fed beta-carotene (betaC-KO) had significantly lower hepatic vitamin A concentrations (17% of WT mice fed beta-carotene [betaC-WT]). Concordantly, betaC-KO mice had higher serum and tissue beta-carotene concentrations than betaC-WT mice. In addition, phenotypically CMO I KO mice had significantly higher final body weights and CMO I KO female mice had significantly lower uterus weights than CMO I WT mice. In conclusion, CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.org/dc/terms/identifier | "doi:10.3945/jn.108.099663"xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "Wyss A."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "Lu C.H."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "King J.L."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "Erdman J.W. Jr."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "Goralczyk R."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "Ford N.A."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/author | "Lindshield B.L."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/name | "J Nutr"xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/pages | "2367-2371"xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/title | "Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice."xsd:string |
| http://purl.uniprot.org/citations/19022959 | http://purl.uniprot.org/core/volume | "138"xsd:string |
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