| http://purl.uniprot.org/citations/19023403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19023403 | http://www.w3.org/2000/01/rdf-schema#comment | "The kinetochore is a protein complex that assembles on centromeric DNA to mediate chromosome-microtubule interaction. Most eukaryotic cells form the spindle and establish kinetochore-microtubule interaction during mitosis, but budding yeast cells finish these processes in S-phase. It has long been noticed that the S-phase spindle in budding yeast is shorter than that in metaphase, but the biological significance of this short S-phase spindle structure remains unclear. We addressed this issue by using ask1-3, a temperature-sensitive kinetochore mutant that exhibits partially elongated spindles at permissive temperature in the presence of hydroxyurea (HU), a DNA synthesis inhibitor. After exposure to and removal of HU, ask1-3 cells show a delayed anaphase entry. This delay depends on the spindle checkpoint, which monitors kinetochore-microtubule interaction defects. Overproduction of microtubule-associated protein Ase1 or Cin8 also induces spindle elongation in HU-arrested cells. The spindle checkpoint-dependent anaphase entry delay is also observed after ASE1 or CIN8 overexpression in HU-arrested cells. Therefore, the shorter spindle in S-phase cells is likely to facilitate proper chromosome-microtubule interaction."xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000262"xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/author | "Jin F."xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/author | "Liang F."xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/pages | "e1000262"xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/title | "The coordination of centromere replication, spindle formation, and kinetochore-microtubule interaction in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/19023403 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P40316-mappedCitation-19023403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19023403 |
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| http://purl.uniprot.org/uniprot/#_P40957-mappedCitation-19023403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19023403 |
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| http://purl.uniprot.org/uniprot/P50275 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19023403 |
| http://purl.uniprot.org/uniprot/P32797 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19023403 |