| http://purl.uniprot.org/citations/19028597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19028597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19028597 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cell maturation is the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T cell responses. Although some mechanistic aspects of DC maturation have begun to be characterised, very little is known about the genetic events regulating the ubiquitin-proteasome system which plays a key role at various levels of the immune response. Therefore, we here investigated the expression of more than 1000 genes related to the ubiquitin-proteasome system in maturing dendritic cells following various stimuli and identified a specific set of transcripts induced by lipopolysaccharide and/or Poly(I:C) which is largely distinct from that induced by CD40 ligand or pro-inflammatory cytokines. This group of genes was dependent on a type I interferon autocrine loop and included E1 and E2 enzymes, E3-ligases, de-ubiquitylating enzymes, proteasome components as well as the ubiquitin-like modifiers ISG15 and FAT10. We further demonstrate that the increased expression of the E2 enzyme UBE2L6 (UbcH8) is required for efficient antigen cross-presentation by dendritic cells. In summary, our data underline the importance of remodelling the ubiquitin-proteasome system for dendritic cell function."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2008.10.023"xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biocel.2008.10.023"xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Urban S."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Urban S."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Krueger E."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Krueger E."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Lange N."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Lange N."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Ebstein F."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Ebstein F."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Kloetzel P.-M."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Kloetzel P.-M."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Seifert U."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/author | "Seifert U."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/name | "Int. J. Biochem. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/name | "Int. J. Biochem. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/pages | "1205-1215"xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/pages | "1205-1215"xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/title | "Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system."xsd:string |
| http://purl.uniprot.org/citations/19028597 | http://purl.uniprot.org/core/title | "Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system."xsd:string |