| http://purl.uniprot.org/citations/19028685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19028685 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously we determined that inflammation responsive transcription factors AP-1 and SAF-1 synergistically regulate transcriptional induction of the MMP-1 gene. The present study investigated the underlying molecular mechanism of cooperativity between these two different groups of transcription factors. We present evidence that knockdown of SAF-1 by small interfering RNAs inhibits AP-1-mediated increase of human MMP-1 expression. The two key members of the AP-1 family of proteins, c-Fos and c-Jun, and SAF-1 form a ternary protein complex, which has markedly higher DNA binding activity than either a SAF-1 homodimer or a c-Fos/c-Jun heterodimer. The increased DNA binding activity of the ternary complex is translated into a striking enhancement of their transcriptional activity by which synergistic transcriptional induction of MMP-1 expression is achieved. The SAF-1.c-Fos.c-Jun ternary complex efficiently promotes transcription from both SAF-1 and AP-1 sites of human MMP-1 promoter. The physical interaction between SAF-1 and AP-1 was demonstrated both in vitro by Far-Western and antibody pulldown assays with recombinant proteins and in vivo by chromatin immunoprecipitation (ChIP), re-ChIP, and co-immunoprecipitation analyses. Two distinct but adjacent domains in SAF-1 are involved in protein-protein contact with c-Fos and c-Jun; one domain resides within two N-terminal polyalanine tracts, and the other is present within the first two zinc finger motifs. Together these findings delineate the mechanism of synergy and the essential role of SAF-1 and AP-1 in up-regulating human MMP-1 expression under various inflammatory conditions."xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806289200"xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/author | "Kumar D."xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/author | "Ray A."xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/author | "Ray B.K."xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/pages | "1853-1862"xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/title | "Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1."xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19028685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19028685 |
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