| http://purl.uniprot.org/citations/19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19028697 | http://www.w3.org/2000/01/rdf-schema#comment | "The efficient and regulated response to cellular stress is coordinated by a genetic regulatory network in which a given transcription factor controls the expression of diverse target genes depending on the cell type and/or nature of the stimuli. The tumor suppressor p53 is thought to preferentially regulate the balance between cell survival and death. The interferon regulatory factor 5 (IRF-5), known to be involved in the innate immune response to pathogens, is also a critical regulator of DNA damage-induced apoptosis. Here, we provide direct evidence that IRF-5 promotes apoptosis upon signaling through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptors (DR). We report that IRF-5 sensitizes tumor cells to TRAIL-induced apoptosis and cell death that is further enhanced by type I interferons. Cells deficient of IRF-5 gave a significantly diminished response to these agents. IRF-5 is involved in DR signaling upstream of caspase 8, in part because of an IRF-5-dependent increase in caspase 8 activation. We provide evidence that TRAIL induces a signaling cascade that leads to the phosphorylation and nuclear localization of IRF-5, resulting in transactivation of key DR signaling components. The results presented here identify IRF-5 as a new mediator of DR signaling and provides molecular insight into the mechanism of TRAIL-induced IRF-5 signaling."xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m804744200"xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/author | "Hu G."xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/author | "Barnes B.J."xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/pages | "2767-2777"xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/title | "IRF-5 is a mediator of the death receptor-induced apoptotic signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19028697 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19028697 |
| http://purl.uniprot.org/citations/19028697 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19028697 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SVY5-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_E9Q5T2-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_P56477-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
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| http://purl.uniprot.org/uniprot/#_A0A0G2USB5-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_A0A0G2UUJ1-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_B7Z1M2-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_B2CC69-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_A9LSF3-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_A9LSF4-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_A9LSF6-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_B4DLN8-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |
| http://purl.uniprot.org/uniprot/#_I6YQ35-mappedCitation-19028697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19028697 |