| http://purl.uniprot.org/citations/19028838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19028838 | http://www.w3.org/2000/01/rdf-schema#comment | "Inositide-specific phospholipase Cbeta1 (PLCbeta1) signaling in cell proliferation has been investigated thoroughly in the G(1) cell cycle phase. However, little is known about its involvement in G(2)/M progression. We used murine erythroleukemia cells to investigate the role of PLCbeta1 in G(2)/M cell cycle progression and screened a number of candidate intermediate players, particularly mitogen-activated protein kinase (MAPK) and protein kinase C (PKC), which can, potentially, transduce serum mitogenic stimulus and induce lamin B1 phosphorylation, leading to G(2)/M progression. We report that PLCbeta1 colocalizes and physically interacts with lamin B1. Studies of the effects of inhibitors and selective si-RNA mediated silencing showed a role of JNK, PKCalpha, PKCbetaI, and the beta1 isoform of PI-PLC in cell accumulation in G(2)/M [as observed by fluorescence-activated cell sorter (FACS)]. To shed light on the mechanism, we considered that the final signaling target was lamin B1 phosphorylation. When JNK, PKCalpha, or PLCbeta1 were silenced, lamin B1 exhibited a lower extent of phosphorylation, as compared to control. The salient features to emerge from these studies are a common pathway in which JNK is likely to represent a link between mitogenic stimulus and activation of PLCbeta1, and, foremost, the finding that the PLCbeta1-mediated pathway represents a functional nuclear inositide signaling in the G(2)/M transition."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.08-121244"xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Cocco L."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Teti G."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Chiarini F."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Billi A.M."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Faenza I."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Mazzotti G."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Fiume R."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/author | "Ramazzotti G."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/pages | "957-966"xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/title | "Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression."xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/19028838 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19028838 |
| http://purl.uniprot.org/citations/19028838 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19028838 |
| http://purl.uniprot.org/uniprot/P14733#attribution-0C19880C19C0659F9D7053625E590808 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19028838 |
| http://purl.uniprot.org/uniprot/P14733#attribution-98A93591B64097902AF6319E62CBDFBE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19028838 |
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| http://purl.uniprot.org/uniprot/Q9Z1B3#attribution-98A93591B64097902AF6319E62CBDFBE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19028838 |
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